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Friday, July 17, 2020 | History

2 edition of Proto-Oncogene expression in the nervous /system found in the catalog.

Proto-Oncogene expression in the nervous /system

James I. Morgan

Proto-Oncogene expression in the nervous /system

by James I. Morgan

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  • 9 Currently reading

Published by Published by Elsevier for the Foundation for the study of the Nervous System (FESN) in Amsterdam .
Written in English

    Subjects:
  • Genetic regulation,
  • Proto-oncogenes

  • Edition Notes

    Statementby James I. Morgan.
    SeriesDiscussions in neuroscience -- v. 7, no.4 (1991), Discussions in neurosciences -- v. 7, no. 4
    ContributionsFondation pour l"étude du système nerveux central et périphérique.
    The Physical Object
    Pagination50 p. :
    Number of Pages50
    ID Numbers
    Open LibraryOL18669723M

      Sometimes a proto-oncogene is relocated to another site on a chromosome, and because of the location, there is a higher expression (larger amounts of the protein is produced). Other times, a proto-oncogene may become fused with another gene that makes the proto-oncogene (now an oncogene) more active. We have isolated and characterized the zebrafish ortholog of c-ret, a gene essential for renal organogenesis and enteric nervous system development in mammals. During zebrafish embryogenesis c-ret transcripts are expressed in a number of tissues including spinal motoneurons, pronephric ducts, cranial ganglia, pharyngeal arches, and the enteric.

    Emotion refers to the dynamic changes of feeling accompanied by the alteration of physical and visceral activities. Autonomic nervous system (sympathetic and parasympathetic) regulates the visceral activities. Therefore, monitoring and analyzing autonomic nervous activity help understand the emotion . Prenatal exposure to ethanol causes neuronal death in somatosensory cortex, but apparently not in the ventrobasal nucleus of the thalamus. Effectors such as bcl-2, bax, and caspase 3 can determine whether a neuron survives or dies. We hypothesize that ethanol differentially affects the expression of .

    Reduction of the P5A-ATPase Spf1p phosphoenzyme by a Ca2+-dependent phosphatase. Corradi, Gerardo R; Mazzitelli, Luciana R; Petrovich, Guido D; Grenon, Paula. Tumors of the peripheral nervous system include neuroblastomas, pheochromocytomas, and neuroepitheliomas. Neuroblastomas and pheochromocytomas are adrenergic in .


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Proto-Oncogene expression in the nervous /system by James I. Morgan Download PDF EPUB FB2

Abstract. I show, by in situ hybridization, that c-fos is expressed in the nervous system during mouse development. This expression was found to be restricted to specific regions at late stages of development (day 16 postcoitum), particularly to the spinal cord, dorsal root ganglia, and olfactory by: Proto-oncogene expression in the nervous system.

Amsterdam ; New York: Elsevier Science Publishers, B.V., © (OCoLC) Document Type: Book: All Authors / Contributors: James I Morgan; Fondation pour l'étude du système nerveux central et périphérique. Proto-oncogenes have derived their names from the respective retroviral diseases in which their homologs were discovered (Table ).Examples of different proto-oncogenes, their retroviral counterparts, species of origin, and their encoded protein products are presented in Table Proto-oncogenes encode intracellular regulatory proteins (e.g., protein kinases), growth factors, and growth.

Purchase Gene Expression in the Central Nervous System, Volume - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1. The 3e is a complete and updated revision, with new chapters covering genes and anatomy, gene expression studies, and glia cells.

The book continues to be an excellent companion to the Atlas of the Human Brain, and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy. Hartl, K. Bister, in Brenner's Encyclopedia of Genetics (Second Edition), Abstract.

Oncogenes are eukaryotic genes that have the potential to become dominant oncogenic determinants in tumorigenesis. They are mutant alleles of normal cellular genes, termed protooncogenes, that are preserved in evolution and have essential physiological functions in normal cells.

Prdm8, 12 and 13 show restricted nervous system expression from early embryogenesis. To examine the expression of Prdm5–16 in detail, we carried out whole mount in situ hybridization (WISH) at E and E Three Prdm genes (8, 12 and 13) showed spatially restricted expression in nervous system.

The N-myc proto-oncogene is expressed during embryogenesis, suggesting that it plays a role in normal development. Since the myc-family oncogenes have been implicated in the control of cell growth, the embryonic expression may reflect rapid proliferation known to occur in development.

Oncogene, genetic material that carries the ability to induce oncogene is a sequence of deoxyribonucleic acid that has been altered or mutated from its original form, the ing as a positive growth regulator, the proto-oncogene is involved in promoting the differentiation and proliferation of normal cells.A variety of proto-oncogenes are involved in different.

Finally, p53 expression levels in brain tumors were comparable to Bcl-6 levels. Overall, these data demonstrate, for the first time, that the Bcl-6 gene translocates in GBM patients and that its translocation and expression are correlated with apoptosis inhibition, indicating a key role for this gene in the control of cellular proliferation.

Morgan JI, Curran T. Proto-oncogene transcription factors and epilepsy. Trends Pharmacol Sci. Sep; 12 (9)– Morgan JI, Curran T. Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun. Annu Rev Neurosci.

; – A proto-oncogene is a normal gene that can become an oncogene due to mutations. Functions of oncogenes: Over-expression of proto-oncogene required for the production of growth factors. The transformed cell will produce growth factor in autocrine pattern.

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma. Nature. Jan 27; ()– Ikeda I, Ishizaka Y, Tahira T, Suzuki T, Onda M, Sugimura T, Nagao M. Specific expression of the ret proto-oncogene in human neuroblastoma cell lines.

Oncogene. The present study was addressed to find out the expression of Bcl2 proto-oncogene in tumor tissues derived from 25 patients with primary central nervous system tumors.

Brain parenchyma in 8 cases, with deeply located tumor, was also examined for Bcl2. c-fos Proto-oncogene expression in the nervous system during mouse development Article (PDF Available) in Molecular and Cellular Biology 9(5).

The Nervous System Functions of the Nervous System 1. Gathers information from both inside and outside the body - Sensory Function 2. Transmits information to the processing areas of the brain and spine 3.

Processes the information in the brain and spine – Integration Function 4. (Part of book or chapter of book) Abstract. Tumors of the peripheral nervous system include neuroblastomas, pheochromocytomas, and neuroepitheliomas.

Neuroblastomas and pheochromocytomas are adrenergic in origin and share certain genetic features, whereas neuroepitheliomas are thought to be cholinergic and are characterized by distinct genetic.

H.M. Mehendale, J. Chilakapati, in Comprehensive Toxicology, Alterations in proto-oncogene expression. Proto-oncogene expressions appear to play an important role in the stimulation of cellular proliferation during tissue regeneration (Thompson et al.

).Liver regeneration is accompanied by a dramatic early increase in the expression of DNA synthesis of c-myc and other. Human nervous system - Human nervous system - Receptors: Receptors are biological transducers that convert energy from both external and internal environments into electrical impulses.

They may be massed together to form a sense organ, such as the eye or ear, or they may be scattered, as are those of the skin and viscera. Receptors are connected to the central nervous system by afferent nerve.

The present study was addressed to find out the expression of Bcl2 proto-oncogene in tumor tissues derived from 25 patients with primary central nervous system tumors. Brain parenchyma in 8 cases, with deeply located tumor, was also examined for Bcl2 expression which served as control.

The RET proto-oncogene (OMIM ) is the main gene associated with HSCR [5,6,7], although there are many other genes related to the disease, among which most are involved in the development of the Enteric Nervous System (ENS). The RET proto-oncogene is responsible for the development of several human inherited and non-inherited diseases.

Germline point mutations were identified in multiple endocrine neoplasia types 2A and 2B, and familial medullary thyroid carcinoma. More than 10 rearranged forms of RET, referred to as RET/PTC 1–9, ELKS/RET and RFP/RET, have been cloned from sporadic and radiation .Proto-oncogene.

A proto-oncogene is a normal gene that could become an oncogene due to mutations or increased expression. Proto-oncogenes code for proteins that help to regulate the cell growth and differentiation.

Proto-oncogenes are often involved in signal transduction and execution of mitogenic signals, usually through their protein products.